Highly Diastereoselective Synthesis of Spiropyrazolones
Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK
Department of Chemistry, Obafemi Awolowo University, Ile-Ife 220005, Nigeria
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Raquel P. Herrera
Received: 28 April 2015 / Revised: 8 May 2015 / Accepted: 11 May 2015 / Published: 13 May 2015
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
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MDPI and ACS Style
Ceban, V.; Olomola, T.O.; Meazza, M.; Rios, R. Highly Diastereoselective Synthesis of Spiropyrazolones. Molecules 2015, 20, 8574-8582.
Ceban V, Olomola TO, Meazza M, Rios R. Highly Diastereoselective Synthesis of Spiropyrazolones. Molecules. 2015; 20(5):8574-8582.
Ceban, Victor; Olomola, Temitope O.; Meazza, Marta; Rios, Ramon. 2015. "Highly Diastereoselective Synthesis of Spiropyrazolones." Molecules 20, no. 5: 8574-8582.
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