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Communication

Highly Diastereoselective Synthesis of Spiropyrazolones

by 1,†, 1,2,†, 1,† and 1,*
1
Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK
2
Department of Chemistry, Obafemi Awolowo University, Ile-Ife 220005, Nigeria
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Raquel P. Herrera
Molecules 2015, 20(5), 8574-8582; https://doi.org/10.3390/molecules20058574
Received: 28 April 2015 / Revised: 8 May 2015 / Accepted: 11 May 2015 / Published: 13 May 2015
(This article belongs to the Collection Recent Advances in Organocatalysis)
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields. View Full-Text
Keywords: spiropyrazolones; diastereoselective; cascade reaction spiropyrazolones; diastereoselective; cascade reaction
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MDPI and ACS Style

Ceban, V.; Olomola, T.O.; Meazza, M.; Rios, R. Highly Diastereoselective Synthesis of Spiropyrazolones. Molecules 2015, 20, 8574-8582. https://doi.org/10.3390/molecules20058574

AMA Style

Ceban V, Olomola TO, Meazza M, Rios R. Highly Diastereoselective Synthesis of Spiropyrazolones. Molecules. 2015; 20(5):8574-8582. https://doi.org/10.3390/molecules20058574

Chicago/Turabian Style

Ceban, Victor, Temitope O. Olomola, Marta Meazza, and Ramon Rios. 2015. "Highly Diastereoselective Synthesis of Spiropyrazolones" Molecules 20, no. 5: 8574-8582. https://doi.org/10.3390/molecules20058574

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