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Molecules 2015, 20(4), 6520-6532;

A Facile Synthesis and Antimicrobial Activity Evaluation of Sydnonyl-Substituted Thiazolidine Derivatives

Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan City 71005, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 10 February 2015 / Revised: 23 March 2015 / Accepted: 2 April 2015 / Published: 13 April 2015
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Some new sydnonyl-substituted thiazolidine derivatives were synthesized in high yields by the modified Knoevenagel condensation of 3-aryl-4-formylsydnones with thiazolidine-2,4-dione and 2-thioxo-thiazolidine-4-one, respectively. All the synthesized thiazolidine derivatives were screened by paper-disc method to identify their antimicrobial activities against three bacteria viz. Staphylococcus aureus, Proteus vulgaris and Escherichia coli, and two fungal cultures viz. Aspergillus niger and Penicillium citrinum. The reference drugs were Norfloxacin and Griseofulvin, respectively. The screening data indicated that the tested sydnonyl-substituted thiazolidine derivatives exhibited no obvious antibacterial activity compared with the standard drug Norfloxacin. However, thiazolidine derivatives displayed significant antifungal activities against Penicillium citrinum and Aspergillus niger. Notably, all of the tested compounds showed growth inhibitory activity 1.5-4.4 times higher than that of the standard drug Griseofulvin against the two fungi. View Full-Text
Keywords: Knoevenagel reaction; sydnones; thiazolidines; antimicrobial activity Knoevenagel reaction; sydnones; thiazolidines; antimicrobial activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shih, M.-H.; Xu, Y.-Y.; Yang, Y.-S.; Lin, G.-L. A Facile Synthesis and Antimicrobial Activity Evaluation of Sydnonyl-Substituted Thiazolidine Derivatives. Molecules 2015, 20, 6520-6532.

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