Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.
AbstractJatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby reducing insulin resistance induced by fatty acids compared to the basal control. A chromatographic fraction applied intraperitoneally (IP) in mice reduced glucose by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. A flavanone was purified from this active fraction and its structure was assigned by 1H- and 13C-NMR (1D and 2D) and MS. This compound retains the previously reported activity, stimulating in vitro the glucose uptake in a concentration-dependent manner. This study indicates that Jatropha gossypifolia L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also improving glucose tolerance in an in vivo model. View Full-Text
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Granados, S.; Balcázar, N.; Guillén, A.; Echeverri, F. Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.. Molecules 2015, 20, 6181-6193.
Granados S, Balcázar N, Guillén A, Echeverri F. Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.. Molecules. 2015; 20(4):6181-6193.Chicago/Turabian Style
Granados, Sergio; Balcázar, Norman; Guillén, Alis; Echeverri, Fernando. 2015. "Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.." Molecules 20, no. 4: 6181-6193.