Next Article in Journal
Comparison of Two Species of Notopterygium by GC-MS and HPLC
Previous Article in Journal
(−)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(3), 5050-5061;

Design, Synthesis and Insecticidal Activity of Novel Phenylurea Derivatives

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 28 February 2015 / Revised: 14 March 2015 / Accepted: 17 March 2015 / Published: 19 March 2015
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [692 KB, uploaded 19 March 2015]   |  


A series of novel phenylurea derivatives were designed and synthesized according to the method of active groups linkage and the principle of aromatic groups bioisosterism in this study. The structures of the novel phenylurea derivatives were confirmed based on ESI-MS, IR and 1H-NMR spectral data. All of the compounds were evaluated for the insecticidal activity against the third instars larvae of Spodoptera exigua Hiibner, Plutella xyllostella Linnaeus, Helicoverpa armigera Hubner and Pieris rapae Linne respectively, at the concentration of 10 mg/L. The results showed that all of the derivatives displayed strong insecticidal activity. Most of the compounds presented higher insecticidal activity against S. exigua than the reference compounds tebufenozide, chlorbenzuron and metaflumizone. Among the synthesized compounds, 3b, 3d, 3f, 4b and 4g displayed broad spectrum insecticidal activity. View Full-Text
Keywords: phenylurea; diacylhydrazine; metaflumizone; insecticidal activity; synthesis phenylurea; diacylhydrazine; metaflumizone; insecticidal activity; synthesis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Sun, J.; Zhou, Y. Design, Synthesis and Insecticidal Activity of Novel Phenylurea Derivatives. Molecules 2015, 20, 5050-5061.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top