Anti-Tumor Activity of a Polysaccharide from Blueberry
1
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China
2
College of Land and Environment, Shenyang Agricultural University, Shenyang 110866, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(3), 3841-3853; https://doi.org/10.3390/molecules20033841
Received: 20 January 2015 / Revised: 16 February 2015 / Accepted: 16 February 2015 / Published: 27 February 2015
(This article belongs to the Section Natural Products Chemistry)
Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg−1·d−1) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-α, IFN-γ, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator.
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Keywords:
blueberry; a bioactive polysaccharide; anti-tumor; immunoregulation
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MDPI and ACS Style
Sun, X.; Liu, N.; Wu, Z.; Feng, Y.; Meng, X. Anti-Tumor Activity of a Polysaccharide from Blueberry. Molecules 2015, 20, 3841-3853. https://doi.org/10.3390/molecules20033841
AMA Style
Sun X, Liu N, Wu Z, Feng Y, Meng X. Anti-Tumor Activity of a Polysaccharide from Blueberry. Molecules. 2015; 20(3):3841-3853. https://doi.org/10.3390/molecules20033841
Chicago/Turabian StyleSun, Xiyun; Liu, Ning; Wu, Zhaoxia; Feng, Ying; Meng, Xianjun. 2015. "Anti-Tumor Activity of a Polysaccharide from Blueberry" Molecules 20, no. 3: 3841-3853. https://doi.org/10.3390/molecules20033841
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