Next Article in Journal
Significant Improvement of Optoelectronic and Photovoltaic Properties by Incorporating Thiophene in a Solution-Processable D–A–D Modular Chromophore
Next Article in Special Issue
The Tissue Distribution and Urinary Excretion Study of Gallic Acid and Protocatechuic Acid after Oral Administration of Polygonum Capitatum Extract in Rats
Previous Article in Journal
Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(12), 21770-21786;

In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries

Department of Physiology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Number 1–3, Clinicilor Street, RO-400023 Cluj-Napoca, Romania
Department of Physiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Number 8, Victor Babes Street, RO-400012 Cluj-Napoca, Romania
Department of Veterinary Toxicology, University of Agricultural Sciences and Veterinary Medicine, Number 3–5, Mănăştur Street, RO-400372 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Academic Editor: Rafael Llorach
Received: 24 October 2015 / Revised: 26 November 2015 / Accepted: 30 November 2015 / Published: 4 December 2015
Full-Text   |   PDF [1883 KB, uploaded 4 December 2015]   |  


Background: Diabetes mellitus (DM) is a chronic endocrine-metabolic disorder associated with endothelial dysfunction. Hyperglycemia, dyslipidemia and abnormal nitric oxide-mediated vasodilatation are the major causal factors in the development of endothelial dysfunction in DM. The prevention of endothelial dysfunction may be a first target against the appearance of atherosclerosis and cardiovascular diseases. We have investigated the synergistic protective effects of quercetin administration and moderate exercise training on thoracic aorta injuries induced by diabetes. Methods: Diabetic rats that performed exercise training were subjected to a swimming training program (1 h/day, 5 days/week, 4 weeks). The diabetic rats received quercetin (30 mg/kg body weight/day) for 4 weeks. At the end of the study, the thoracic aorta was isolated and divided into two parts; one part was immersed in 10% formalin for histopathological evaluations and the other was frozen for the assessment of oxidative stress markers (malondialdehyde, MDA and protein carbonyls groups, PC), the activity of antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT), nitrite plus nitrate (NOx) production and inducible nitric oxide synthase (iNOS) protein expression. Results: Diabetic rats showed significantly increased MDA and PC levels, NOx production and iNOS expression and a reduction of SOD and CAT activity in aortic tissues. A decrease in the levels of oxidative stress markers, NOx production and iNOS expression associated with elevated activity of antioxidant enzymes in the aortic tissue were observed in quercetin-treated diabetic trained rats. Conclusions: These findings suggest that quercetin administration in association with moderate exercise training reduces vascular complications and tissue injuries induced by diabetes in rat aorta by decreasing oxidative stress and restoring NO bioavailability. View Full-Text
Keywords: endothelial dysfunction; diabetes mellitus; quercetin; exercise training endothelial dysfunction; diabetes mellitus; quercetin; exercise training

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Chis, I.C.; Coseriu, A.; Simedrea, R.; Oros, A.; Nagy, A.L.; Clichici, S. In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries. Molecules 2015, 20, 21770-21786.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top