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Open AccessArticle

A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats

by Yuming Wang 1,2, Xuejun Guo 1,2, Jiabin Xie 1,2, Zhiguo Hou 1,2 and Yubo Li 1,2,*
1
School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China
2
Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(12), 21364-21372; https://doi.org/10.3390/molecules201219776
Received: 7 October 2015 / Revised: 18 November 2015 / Accepted: 19 November 2015 / Published: 1 December 2015
(This article belongs to the Section Metabolites)
Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). An orthogonal partial least-square discriminant analysis (OPLS-DA) model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions. View Full-Text
Keywords: GC-MS; metabonomics; rheumatoid arthritis; Simiaowan GC-MS; metabonomics; rheumatoid arthritis; Simiaowan
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Wang, Y.; Guo, X.; Xie, J.; Hou, Z.; Li, Y. A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats. Molecules 2015, 20, 21364-21372.

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