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Open AccessArticle

Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr.

1
College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China
2
School of Pharmacy, Wannan Medical College, Wuhu 241002, Anhui, China
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(12), 21494-21500; https://doi.org/10.3390/molecules201219775
Received: 21 October 2015 / Revised: 11 November 2015 / Accepted: 16 November 2015 / Published: 2 December 2015
(This article belongs to the Section Natural Products Chemistry)
Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides exhibited strong inhibitory activities against xanthine oxidase in vitro. Their half-maximal inhibitory concentrations (IC50) were calculated, which were 9.48, 8.31, 16.00 μM, respectively. View Full-Text
Keywords: Polygala sibirica; Polygalaceae; flavonol glycosides; inhibition of xanthine oxidase Polygala sibirica; Polygalaceae; flavonol glycosides; inhibition of xanthine oxidase
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Huang, Y.-J.; Zhou, L.-Y.; Wang, J.-M.; Li, Q.; Geng, Y.-Y.; Liu, H.-Y.; Hua, Y. Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr.. Molecules 2015, 20, 21494-21500.

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