Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers
AbstractStereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (−)-cis-EC, (+)-trans-EC, and (−)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the animals. In the maximal electroshock-induced seizures (MES) test, prevention of tonic seizures was also verified for all of the isomers tested. However, the isomeric forms (+) and (−)-trans-EC showed 25% and 12.5% inhibition of convulsions, respectively. In the pilocarpine-induced seizures test, all stereoisomers demonstrated an anticonvulsant profile, yet the stereoisomers (+) and (−)-trans-EC (at 300 mg/kg) showed a more pronounced effect. A strychnine-induced anticonvulsant test was performed, and none of the stereoisomers significantly increased the latency to onset of convulsions; the stereoisomers probably do not act in this pathway. However, the stereoisomers (+)-cis-EC and (+)-trans-EC greatly increased the latency to death of the animals, thus presenting some protection. The four EC stereoisomers show promise for anticonvulsant activity, an effect emphasized in the isomers (+)-cis-EC, (+)-trans-EC, and (−)-trans-EC for certain parameters of the tested methodologies. These results serve as support for further research and development of antiepileptic drugs from monoterpenes. View Full-Text
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Salgado, P.R.R.; Da Fonsêca, D.V.; Braga, R.M.; De Melo, C.G.F.; Andrade, L.N.; De Almeida, R.N.; De Sousa, D.P. Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers. Molecules 2015, 20, 19660-19673.
Salgado PRR, Da Fonsêca DV, Braga RM, De Melo CGF, Andrade LN, De Almeida RN, De Sousa DP. Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers. Molecules. 2015; 20(11):19660-19673.Chicago/Turabian Style
Salgado, Paula R.R.; Da Fonsêca, Diogo V.; Braga, Renan M.; De Melo, Cynthia G.F.; Andrade, Luciana N.; De Almeida, Reinaldo N.; De Sousa, Damião P. 2015. "Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers." Molecules 20, no. 11: 19660-19673.