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Molecules 2015, 20(1), 738-753;

On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

Nano-Science Center and Department of Chemistry, University of Copenhagen, Copenhagen 2100, Denmark
European Spallation Source ESS A/S, Lund 22363, Sweden
Institute of Organic Chemistry, Polish Academy of Science, Warsaw 01-224, Poland
Department of Biomedical Sciences and Biofilm Research Center, Health & Society, Malmoe University, Malmoe 20500, Sweden
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 November 2014 / Accepted: 22 December 2014 / Published: 7 January 2015
(This article belongs to the Section Organic Chemistry)
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Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity. View Full-Text
Keywords: dendrimers; peptide; antimicrobial; lipids dendrimers; peptide; antimicrobial; lipids

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Lind, T.K.; Polcyn, P.; Zielinska, P.; Cárdenas, M.; Urbanczyk-Lipkowska, Z. On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture. Molecules 2015, 20, 738-753.

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