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Molecules 2014, 19(9), 14266-14272; https://doi.org/10.3390/molecules190914266

Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya

1
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China
2
College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 August 2014 / Revised: 2 September 2014 / Accepted: 3 September 2014 / Published: 11 September 2014
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Two new sesquiterpenoids with guaiane skeletons—holosericin A (1) and holosericin B (2)—were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition. View Full-Text
Keywords: Thymelaeaceae; Daphne holosericea; guaiane sesquiterpenoids; acetylcholinesterase inhibition Thymelaeaceae; Daphne holosericea; guaiane sesquiterpenoids; acetylcholinesterase inhibition
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Ma, Q.-Y.; Chen, Y.-C.; Huang, S.-Z.; Guo, Z.-K.; Dai, H.-F.; Hua, Y.; Zhao, Y.-X. Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya. Molecules 2014, 19, 14266-14272.

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