Next Article in Journal
Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells
Next Article in Special Issue
Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation
Previous Article in Journal
Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
Previous Article in Special Issue
Isocorydine Derivatives and Their Anticancer Activities
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 13177-13187;

Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment

Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Author to whom correspondence should be addressed.
Received: 12 May 2014 / Revised: 9 July 2014 / Accepted: 15 July 2014 / Published: 26 August 2014
Full-Text   |   PDF [1981 KB, uploaded 26 August 2014]   |  


Cholesterol-conjugated 5-fluorouracil prodrugs were designed to be carried in vivo via low density lipoproteins (LDL) and subsequently undergo LDL-receptor-mediated internalisation into cancer cells. In vivo anti-cancer evaluation was performed using 5-fluorouracil-cholesterol conjugate in a mouse model. The obtained prodrugs were more potent than 5-fluorouracil control drug at the same 5-fluorouracil content (3 mg·kg−1). View Full-Text
Keywords: drug targeting; anticancer; cholesteryl esters drug targeting; anticancer; cholesteryl esters

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Radwan, A.A.; Alanazi, F.K. Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment. Molecules 2014, 19, 13177-13187.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top