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Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety

by Yanwei Wang 1,3,†, Kehan Xu 1,†, Guojing Bai 1, Lei Huang 1, Qiuye Wu 1, Weihua Pan 2,* and Shichong Yu 1,*
1
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China
2
Shanghai Key Laboratory of Molecular Medical Mycology, Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
3
Department of Pharmacy, No. 422 Hospital of PLA, 40 Haibin No. 3 Road, Zhanjiang 524000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(8), 11333-11340; https://doi.org/10.3390/molecules190811333
Received: 7 June 2014 / Revised: 18 July 2014 / Accepted: 21 July 2014 / Published: 31 July 2014
(This article belongs to the Section Medicinal Chemistry)
Design and synthesis of triazole library antifungal agents having piperazine side chains, analogues to fluconazole were documented. The synthesis highlighted utilization of the click chemistry on the basis of the active site of the cytochrome P450 14α-demethylase (CYP51). Their structures were characterized by 1H-NMR, 13C-NMR, MS and IR. The influences of piperazine moiety on in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. View Full-Text
Keywords: antifungal; triazole; synthesis; piperazine antifungal; triazole; synthesis; piperazine
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MDPI and ACS Style

Wang, Y.; Xu, K.; Bai, G.; Huang, L.; Wu, Q.; Pan, W.; Yu, S. Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety. Molecules 2014, 19, 11333-11340.

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