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Molecules 2014, 19(7), 9089-9100;

Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties

School of Life Sciences, Northeast Normal University, Changchun 130024, China
Pharmacy Department, Chinese People's Liberation Army 208 Hospital, Changchun 130062, China
Author to whom correspondence should be addressed.
Received: 25 May 2014 / Revised: 21 June 2014 / Accepted: 24 June 2014 / Published: 30 June 2014
(This article belongs to the Section Natural Products Chemistry)
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A glucomannan-type polysaccharide, named BSP, was obtained from the tubers of Bletilla striata by ultrasonic-assisted extraction, ethanol precipitation, deproteination and gel-permeation chromatography. HPLC analysis revealed that BSP contained mannose and glucose in the molar ratio of 3.5:1. Its molecular weight (Mw) was estimated to be 20 kDa. Methylation analysis, FT-IR and NMR analyses indicated that BSP consisted of (1→4)-linked β-D-glucopyranosyl residues and (1→4)-linked β-D-mannopyranosyl residues. Cholesteryl succinate was linked to BSP to make it more amphiphilic and the degree of substitution of cholesteryl succinate-BSP was 3.2%. The critical micelle concentration of modified BSP was 0.001 mg/mL, suggesting it could self-assemble into nanoparticles in aqueous solution. View Full-Text
Keywords: cholesteryl-modification; glucomannan; Bletilla striata; hydrogel property cholesteryl-modification; glucomannan; Bletilla striata; hydrogel property

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, M.; Sun, L.; Zhao, W.; Peng, X.; Liu, F.; Wang, Y.; Bi, Y.; Zhang, H.; Zhou, Y. Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties. Molecules 2014, 19, 9089-9100.

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