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Molecules 2014, 19(6), 8289-8302;

A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver

Departamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato. León, 37320, Mexico
Author to whom correspondence should be addressed.
Received: 11 April 2014 / Revised: 6 June 2014 / Accepted: 12 June 2014 / Published: 18 June 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plant of the ginger family which has been used to treat biliary disorders, anorexia, cough, rheumatism, cancer, sinusitis, hepatic disorders, hyperglycemia, obesity, and diabetes in both Ayurvedic and Traditional Chinese Medicine. Suggested mechanisms of action include the modulation of signal transduction cascades and effects on gene expression, however they remain to be elucidated. In this study, the expression of some proteins responsible for transcription factors, inflammation, and metabolic control were evaluated by western blot in 15-week-old db/db mice livers treated with curcumin 0.75% mixed in their diet for 8 weeks. In addition, nitrosative stress was evaluated. Curcumin increased the expression of AMPK and PPARγ, and diminished NF-κB protein in db/db mice. However, it did not modify the expression of PGC-1α or SIRT1. Nitrosative stress present in db/db mice livers was determined by a unique nitrotyrosylated protein band (75 kDa) and was not reverted with curcumin. In conclusion, curcumin regulates the expression of AMPK, PPARγ, and NF-κB; suggesting a beneficial effect for treatment of T2DM complications. In order to observe best beneficial effects it is desirable to administer curcumin in the earlier states of T2DM. View Full-Text
Keywords: antioxidants; Curcuma longa; diabetes; inflammation; obesity; polyphenols antioxidants; Curcuma longa; diabetes; inflammation; obesity; polyphenols

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jiménez-Flores, L.M.; López-Briones, S.; Macías-Cervantes, M.H.; Ramírez-Emiliano, J.; Pérez-Vázquez, V. A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver. Molecules 2014, 19, 8289-8302.

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