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Molecules 2014, 19(6), 6987-7007;

Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines

Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic
Laboratory of Molecular Structure Characterization, Institute of Microbiology, v.v.i., Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague, Czech Republic
Author to whom correspondence should be addressed.
Received: 28 February 2014 / Revised: 13 May 2014 / Accepted: 21 May 2014 / Published: 28 May 2014
(This article belongs to the Special Issue Ruthenium Complex)
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The asymmetric transfer hydrogenation (ATH) of imines catalyzed by the Noyori-Ikariya [RuCl(η6-arene)(N-arylsulfonyl-DPEN)] (DPEN = 1,2-diphenylethylene-1,2-diamine) half-sandwich complexes is a research topic that is still being intensively developed. This article focuses on selected aspects of this catalytic system. First, a great deal of attention is devoted to the N-arylsulfonyl moiety of the catalysts in terms of its interaction with protonated imines (substrates) and amines (components of the hydrogen-donor mixture). The second part is oriented toward the role of the η6-coordinated arene. The final part concerns the imine substrate structural modifications and their importance in connection with ATH. Throughout the text, the summary of known findings is complemented with newly-presented ones, which have been approached both experimentally and computationally. View Full-Text
Keywords: ruthenium; asymmetric hydrogenation; imine; ligand; sulfonyl; arene; DFT ruthenium; asymmetric hydrogenation; imine; ligand; sulfonyl; arene; DFT

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Václavík, J.; Šot, P.; Pecháček, J.; Vilhanová, B.; Matuška, O.; Kuzma, M.; Kačer, P. Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines. Molecules 2014, 19, 6987-7007.

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