Next Article in Journal
Guest-Host Complex Formed between Ascorbic Acid and β-Cyclodextrin Immobilized on the Surface of an Electrode
Previous Article in Journal
Aqueous Solubility and Degradation Kinetics of the Phytochemical Anticancer Thymoquinone; Probing the Effects of Solvents, pH and Light
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(5), 5940-5951; https://doi.org/10.3390/molecules19055940

Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC.

1
Department of Pharmacognosy, College of Pharmacy, King Saud University (KSU), Riyadh 11451, Kingdom of Saudi Arabia
2
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University (MU), Mansoura 35516, Egypt
*
Author to whom correspondence should be addressed.
Received: 20 March 2014 / Revised: 23 April 2014 / Accepted: 4 May 2014 / Published: 9 May 2014
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [366 KB, uploaded 18 June 2014]   |  

Abstract

A phytochemical investigation of the least polar organic extracts of Arnebia hispidissima (Lehm.) DC. roots has led to the isolation of two unique polycyclic geranylhydroquinone-derived metabolites, arnebacene (1) and arnebidin (2), along with some known phenolic metabolites viz., arnebin-7 (3) and vanillic acid (4). The chemical identification of the new isolated compounds, including their relative stereochemistry, was achieved via spectroscopic analyses, including 2D NMR, and spectral comparison with related compounds. A biosynthetic pathway is proposed for the new compounds on the basis of their structure-relationship with previously isolated metabolites. View Full-Text
Keywords: Arnebia hispidissima; arnebacene; arnebidin; arnebin-7; phenolic compounds; geranylhydroquinone Arnebia hispidissima; arnebacene; arnebidin; arnebin-7; phenolic compounds; geranylhydroquinone
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ahmed, A.F.; Saad, H.-E.A.; El-Karim, E.M.A. Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC.. Molecules 2014, 19, 5940-5951.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top