Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC.
1
Department of Pharmacognosy, College of Pharmacy, King Saud University (KSU), Riyadh 11451, Kingdom of Saudi Arabia
2
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University (MU), Mansoura 35516, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(5), 5940-5951; https://doi.org/10.3390/molecules19055940
Received: 20 March 2014 / Revised: 23 April 2014 / Accepted: 4 May 2014 / Published: 9 May 2014
(This article belongs to the Section Natural Products Chemistry)
A phytochemical investigation of the least polar organic extracts of Arnebia hispidissima (Lehm.) DC. roots has led to the isolation of two unique polycyclic geranylhydroquinone-derived metabolites, arnebacene (1) and arnebidin (2), along with some known phenolic metabolites viz., arnebin-7 (3) and vanillic acid (4). The chemical identification of the new isolated compounds, including their relative stereochemistry, was achieved via spectroscopic analyses, including 2D NMR, and spectral comparison with related compounds. A biosynthetic pathway is proposed for the new compounds on the basis of their structure-relationship with previously isolated metabolites.
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Keywords:
Arnebia hispidissima; arnebacene; arnebidin; arnebin-7; phenolic compounds; geranylhydroquinone
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MDPI and ACS Style
Ahmed, A.F.; Saad, H.-E.A.; El-Karim, E.M.A. Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC. Molecules 2014, 19, 5940-5951. https://doi.org/10.3390/molecules19055940
AMA Style
Ahmed AF, Saad H-EA, El-Karim EMA. Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC. Molecules. 2014; 19(5):5940-5951. https://doi.org/10.3390/molecules19055940
Chicago/Turabian StyleAhmed, Atallah F.; Saad, Hassan-Elrady A.; El-Karim, Eman M.A. 2014. "Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC." Molecules 19, no. 5: 5940-5951. https://doi.org/10.3390/molecules19055940
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