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Molecules 2014, 19(4), 4708-4744;

Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes

Department of Biomedical Sciences, Korea University College of Medicine, Seoul 136-705, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 26 February 2014 / Revised: 8 April 2014 / Accepted: 8 April 2014 / Published: 15 April 2014
(This article belongs to the Special Issue Fatty Acids)
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Lipids have long been studied as constituents of the cellular architecture and energy stores in the body. Evidence is now rapidly growing that particular lipid species are also important for molecular and cellular signaling. Here we review the current information on interactions between lipids and transient receptor potential (TRP) ion channels in nociceptive sensory afferents that mediate pain signaling. Sensory neuronal TRP channels play a crucial role in the detection of a variety of external and internal changes, particularly with damaging or pain-eliciting potentials that include noxiously high or low temperatures, stretching, and harmful substances. In addition, recent findings suggest that TRPs also contribute to altering synaptic plasticity that deteriorates chronic pain states. In both of these processes, specific lipids are often generated and have been found to strongly modulate TRP activities, resulting primarily in pain exacerbation. This review summarizes three standpoints viewing those lipid functions for TRP modulations as second messengers, intercellular transmitters, or bilayer building blocks. Based on these hypotheses, we discuss perspectives that account for how the TRP-lipid interaction contributes to the peripheral pain mechanism. Still a number of blurred aspects remain to be examined, which will be answered by future efforts and may help to better control pain states. View Full-Text
Keywords: sensory TRP ion channels; lipids; C-fibers; pain; inflammation sensory TRP ion channels; lipids; C-fibers; pain; inflammation

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Yoo, S.; Lim, J.Y.; Hwang, S.W. Sensory TRP Channel Interactions with Endogenous Lipids and Their Biological Outcomes. Molecules 2014, 19, 4708-4744.

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