Next Article in Journal
Artichoke, Cynarin and Cyanidin Downregulate the Expression of Inducible Nitric Oxide Synthase in Human Coronary Smooth Muscle Cells
Previous Article in Journal
Entrapment of Probiotics in Water Extractable Arabinoxylan Gels: Rheological and Microstructural Characterization
Open AccessArticle

Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

1
Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Gueliz (FSTG), BP 549, Marrakech 40000, Morocco
2
Laboratory of Biomolecular and Medicinal Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Marrakech 40000, Morocco
3
Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main, Max-von-Laue-Strasse 7, D-60438 Frankfurt am Main, Germany
4
Viral Hepatitis Laboratory Pasteur Institute Morocco, 1, Place Louis Pasteur, 20360, Casablanca 20001, Morocco
*
Authors to whom correspondence should be addressed.
Molecules 2014, 19(3), 3638-3653; https://doi.org/10.3390/molecules19033638
Received: 13 January 2014 / Revised: 6 March 2014 / Accepted: 17 March 2014 / Published: 24 March 2014
(This article belongs to the Section Medicinal Chemistry)
In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro. View Full-Text
Keywords: quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV quinazoline ribonucleosides; 1,2,3-triazole-acyclonucleosides; Huisgen cycloaddition; quinazolinone alkylation; HCV
Show Figures

Figure 1

MDPI and ACS Style

Ouahrouch, A.; Taourirte, M.; Engels, J.W.; Benjelloun, S.; Lazrek, H.B. Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues. Molecules 2014, 19, 3638-3653. https://doi.org/10.3390/molecules19033638

AMA Style

Ouahrouch A, Taourirte M, Engels JW, Benjelloun S, Lazrek HB. Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues. Molecules. 2014; 19(3):3638-3653. https://doi.org/10.3390/molecules19033638

Chicago/Turabian Style

Ouahrouch, Abdelaaziz; Taourirte, Moha; Engels, Joachim W.; Benjelloun, Soumaya; Lazrek, Hassan B. 2014. "Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues" Molecules 19, no. 3: 3638-3653. https://doi.org/10.3390/molecules19033638

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop