Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
Abstract
:1. Introduction
2. Results and Discussion
Position | 1 | 2 | |||
---|---|---|---|---|---|
δH | δC | δH | δC | ||
1 | 161.9 | 165.9 | |||
2 | 111.1 | 111.8 | |||
3 | 163.7 | 170.3 | |||
4 | 6.42 s | 93.3 | 105.0 | ||
4a | 156.3 | 158.3 | |||
5 | 7.23 d (9.2) | 116.8 | 7.70 d (8.0) | 115.9 | |
5a | 152.4 | 145.7 | |||
6 | 7.33 d (9.2) | 124.5 | 7.37 dd (8.0, 7.6) | 126.2 | |
7 | 152.5 | 7.44 d (7.6) | 121.9 | ||
8 | 131.1 | 147.4 | |||
8a | 119.6 | 122.1 | |||
9 | 184.3 | 181.9 | |||
9a | 104.3 | 103.0 | |||
10 | 3.37 d (7.2) | 22.1 | 3.36 d (7.2) | 21.6 | |
11 | 5.29 t (7.2) | 123.6 | 5.26 t (7.2) | 122.3 | |
12 | 131.6 | 132.5 | |||
13 | 1.79 s | 18.1 | 1.80 s | 18.0 | |
14 | 1.65 s | 26.0 | 1.66 s | 25.9 | |
15 | 3.49 t (7.6) | 22.6 | 206.1 | ||
16 | 1.84 t (7.6) | 44.5 | 3.67 s | 55.3 | |
17 | 71.1 | 72.0 | |||
18 | 1.30 s | 29.8 | 1.45 s | 30.4 | |
19 | 1.30 s | 29.8 | 1.45 s | 30.4 | |
OH-1 | 13.69 s | 14.33 s a | |||
OH-3 | 9.68 s | 14.40 s a | |||
OH-7 | 8.72 s | ||||
OH-8 | 15.12 s a | ||||
OH-18 | 3.81 s | 2.81 s |
Cancer cell Lines | 1 | 2 | 3 | 4 | 5 | 6 | 7 | Hirsutanol A |
---|---|---|---|---|---|---|---|---|
Human nasopharyngeal carcinoma cell line CNE1 | 1.43 | 2.09 | 0.76 | 16.28 | 6.46 | 15.58 | 1.85 | 10.06 |
Human nasopharyngeal carcinoma cell line CNE2 | 0.73 | 1.21 | 0.54 | 9.04 | 4.51 | 9.77 | 1.81 | 12.70 |
Human nasopharyngeal carcinoma cell line SUNE1 | 2.23 | 2.76 | 2.30 | 24.06 | 8.78 | 11.36 | 4.41 | 3.53 |
Human nasopharyngeal carcinoma cell line HONE1 | – | – | 1.18 | 16.72 | 7.40 | 11.17 | 2.78 | 17.48 |
Human lung cancer cell line A549 | – | – | 1.97 | 20.17 | – | 15.92 | 3.79 | 12.05 |
Human lung cancer cell line GLC82 | – | – | – | 15.38 | 5.52 | 16.97 | 3.46 | 10.11 |
Human breast cancer cell line MCF-7 | – | – | 2.85 | 19.30 | 8.26 | 10.07 | 5.27 | 10.35 |
Human hepatic cancer cell line Bel–7402 | – | – | 3.32 | 16.73 | 7.78 | 11.38 | 3.66 | 24.80 |
3. Experimental
3.1. General Procedures
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Spectral Data
3.5. Cytotoxicity Assay
4. Conclusions
Supplementary Materials
Acknowledgments
Conflicts of Interest
References
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- Sample Availability: Not available.
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Share and Cite
Xu, Z.; Huang, L.; Chen, X.-H.; Zhu, X.-F.; Qian, X.-J.; Feng, G.-K.; Lan, W.-J.; Li, H.-J. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules 2014, 19, 1820-1827. https://doi.org/10.3390/molecules19021820
Xu Z, Huang L, Chen X-H, Zhu X-F, Qian X-J, Feng G-K, Lan W-J, Li H-J. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules. 2014; 19(2):1820-1827. https://doi.org/10.3390/molecules19021820
Chicago/Turabian StyleXu, Zeng, Lei Huang, Xiao-Hong Chen, Xiao-Feng Zhu, Xiao-Jun Qian, Gong-Kan Feng, Wen-Jian Lan, and Hou-Jin Li. 2014. "Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana" Molecules 19, no. 2: 1820-1827. https://doi.org/10.3390/molecules19021820