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Molecules 2014, 19(11), 19137-19151;

Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions

Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland
Author to whom correspondence should be addressed.
Received: 17 October 2014 / Revised: 13 November 2014 / Accepted: 14 November 2014 / Published: 19 November 2014
(This article belongs to the Special Issue Free Radicals and Radical Ions)
Full-Text   |   PDF [864 KB, uploaded 19 November 2014]   |  


The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated “click” process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry. View Full-Text
Keywords: free radical; organic synthesis; carbohydrate; peptide free radical; organic synthesis; carbohydrate; peptide

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Scanlan, E.M.; Corcé, V.; Malone, A. Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions. Molecules 2014, 19, 19137-19151.

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