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Molecules 2014, 19(11), 17839-17847;

A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China
Shanghai Tobacco Group Corporation, Shanghai 200082, China
Beijing Longcredit Essence Biotechnology Co. Ltd, Beijing 100085, China
Author to whom correspondence should be addressed.
Received: 11 September 2014 / Revised: 27 October 2014 / Accepted: 29 October 2014 / Published: 3 November 2014
(This article belongs to the Section Natural Products Chemistry)
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A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey’s method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes. View Full-Text
Keywords: Eurotium cristatum; diketopiperazine; radical scavenging activity Eurotium cristatum; diketopiperazine; radical scavenging activity

Figure 1

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Zou, X.; Li, Y.; Zhang, X.; Li, Q.; Liu, X.; Huang, Y.; Tang, T.; Zheng, S.; Wang, W.; Tang, J. A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum. Molecules 2014, 19, 17839-17847.

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