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Molecules 2014, 19(10), 16770-16778;

A New Urease Inhibitor from Viola betonicifolia

Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan
Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Computational Medicinal Chemistry Laboratory, Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan 23200, Pakistan
Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy
Author to whom correspondence should be addressed.
Received: 13 August 2014 / Revised: 24 September 2014 / Accepted: 25 September 2014 / Published: 17 October 2014
(This article belongs to the Section Natural Products Chemistry)
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Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases. View Full-Text
Keywords: Viola betonicifolia; urease inhibition; kinetic study; molecular modeling Viola betonicifolia; urease inhibition; kinetic study; molecular modeling

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Muhammad, N.; Saeed, M.; Khan, A.; Adhikari, A.; Wadood, A.; Khan, K.M.; De Feo, V. A New Urease Inhibitor from Viola betonicifolia. Molecules 2014, 19, 16770-16778.

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