Next Article in Journal
[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy
Previous Article in Journal
Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(1), 538-549;

Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 11221, Taiwan
Author to whom correspondence should be addressed.
Received: 14 October 2013 / Revised: 2 December 2013 / Accepted: 3 December 2013 / Published: 3 January 2014
Full-Text   |   PDF [200 KB, uploaded 18 June 2014]   |  


The pharmacokinetics of N,N-bis(2-mercapatoethly)-N',N'-diethylenediamine (BMEDA), a molecule that can form a chelate with rhenium-188 (188Re) to produce the 188Re-BMEDA-liposomes, was studied. In this work, beagles received a single injection of BMEDA, at doses of 1, 2, or 5 mg/kg; the concentration of BMEDA in the beagles’ plasma was then analyzed and determined by liquid chromatography-mass spectrometry/mass spectrometry. Based on the pharmacokinetic parameters of BMEDA, we found that male and female animals shared similar patterns indicating that the pharmacokinetics of BMEDA is independent of gender differences. In addition, the pharmacokinetics of BMEDA was seen to be non-linear because the increase of mean AUC0–t and AUC0–∞ values tend to be greater than dose proportional while the mean Vss and CL values of BMEDA appeared to be dose dependent. The information on the pharmacokinetics of BMEDA generated from this study will serve as a basis to design appropriate pharmacology and toxicology studies for future human use. View Full-Text
Keywords: acute toxicity; radiopharmaceutical; BMEDA; 188Re-BMEDA-liposome; pharmacokinetics acute toxicity; radiopharmaceutical; BMEDA; 188Re-BMEDA-liposome; pharmacokinetics

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Chang, C.-H.; Liu, S.-Y.; Lee, T.-W. Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs. Molecules 2014, 19, 538-549.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top