Next Article in Journal
2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as Novel Antifungal Lead Compounds: Biological Evaluation and Structure-Activity Relationships
Previous Article in Journal
Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis
Article Menu

Export Article

Open AccessCommunication
Molecules 2013, 18(9), 10404-10412;

Anti-Inflammatory Effects of Total Isoflavones from Pueraria lobata on Cerebral Ischemia in Rats

Functionality Evaluation Research Group, Korea Food Research Institute, Seongnam 463-746, Korea
Author to whom correspondence should be addressed.
Received: 17 July 2013 / Revised: 21 August 2013 / Accepted: 23 August 2013 / Published: 28 August 2013
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [900 KB, uploaded 18 June 2014]   |  


Puerariae radix, the dried root of Pueraria lobata Ohwi, is one of earliest and most important edible crude herbs used for various medical purposes in Oriental medicine. The aim of the present study was to determine the anti-inflammatory effects of Total Isoflavones from P. lobata (TIPL), which contains the unique isoflavone puerarin, in ischemia in vivo models. Oral administration of TIPL (100 mg/kg) reduced the brain infarct volume and attenuated ischemia-induced cyclooxygenase-2 (COX-2) up-regulation at 2 days after middle cerebral artery occlusion (MCAo) in rats. Moreover, TIPL reduced activation of glial fibrillary acid protein (GFAP) and CD11b antibody (OX-42) at 7 days after MCAo in hippocampal CA1 region. These results show that TIPL can protect the brain from ischemic damage after MCAo. Regarding the immunohistochemical study, the effects of TIPL may be attributable to its anti-inflammatory properties by the inhibition of COX-2 expression, astrocyte expression, and microglia. View Full-Text
Keywords: isoflavones; Pueraria lobata; anti-inflammatory; cerebral ischemia isoflavones; Pueraria lobata; anti-inflammatory; cerebral ischemia

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Lim, D.W.; Lee, C.; Kim, I.-H.; Kim, Y.T. Anti-Inflammatory Effects of Total Isoflavones from Pueraria lobata on Cerebral Ischemia in Rats. Molecules 2013, 18, 10404-10412.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top