Isoliquiritigen Enhances the Antitumour Activity and Decreases the Genotoxic Effect of Cyclophosphamide
Abstract
:1. Introduction
2. Results and Discussion
2.1. High Concentration of ISL Significantly Enhances CP-Induced Inhibition of U14 Cells Proliferation in Vitro
2.2. Co-Treatment with ISL and CP Synergestically Decreases the Tumour Growth in Vivo
2.3. ISL Inhibits the Micronuclei Yield Induced by CP
2.4. ISL Inhibits the DNA Damage Induced by CP
2.5. Discussion
3. Experimental
3.1. Materials
3.2. Animal Preparation
3.3. Cell Culture
3.4. Cell Viability Assay
3.5. Colony Formation Assay
3.6. In Vivo Antitumour Activity Assay
3.7. Micronucleus Formation Assay
3.8. Comet Assay
3.9. Statistical Analysis
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Zhao, H.; Yuan, X.; Li, D.; Chen, H.; Jiang, J.; Wang, Z.; Sun, X.; Zheng, Q. Isoliquiritigen Enhances the Antitumour Activity and Decreases the Genotoxic Effect of Cyclophosphamide. Molecules 2013, 18, 8786-8798. https://doi.org/10.3390/molecules18088786
Zhao H, Yuan X, Li D, Chen H, Jiang J, Wang Z, Sun X, Zheng Q. Isoliquiritigen Enhances the Antitumour Activity and Decreases the Genotoxic Effect of Cyclophosphamide. Molecules. 2013; 18(8):8786-8798. https://doi.org/10.3390/molecules18088786
Chicago/Turabian StyleZhao, Hong, Xuan Yuan, Defang Li, Hongmei Chen, Jiangtao Jiang, Zhiping Wang, Xiling Sun, and Qiusheng Zheng. 2013. "Isoliquiritigen Enhances the Antitumour Activity and Decreases the Genotoxic Effect of Cyclophosphamide" Molecules 18, no. 8: 8786-8798. https://doi.org/10.3390/molecules18088786