Next Article in Journal
Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells
Next Article in Special Issue
Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18
Previous Article in Journal
Novel Antimicrobial Peptide Dendrimers with Amphiphilic Surface and Their Interactions with Phospholipids — Insights from Mass Spectrometry
Previous Article in Special Issue
[Fe2L3]4+ Cylinders Derived from Bis(bidentate) 2-Pyridyl-1,2,3-triazole “Click” Ligands: Synthesis, Structures and Exploration of Biological Activity
Open AccessReview

Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology

by Xiu Zhang and Yan Zhang *
Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine (SCSB), Shanghai Jiao Tong University, 800 Dong Chuan Road, Minhang, Shanghai 200240, China
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(6), 7145-7159; https://doi.org/10.3390/molecules18067145
Received: 20 May 2013 / Revised: 12 June 2013 / Accepted: 14 June 2013 / Published: 19 June 2013
(This article belongs to the Collection Advances in Click Chemistry)
Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments. For glycobiology, bioorthogonal click chemistry has created a new method for glycan non-invasive imaging in living systems, selective metabolic engineering, and offered an elite chemical handle for biological manipulation and glycomics studies. Especially the [3 + 2] dipolar cycloadditions of azides with strained alkynes and the Staudinger ligation of azides and triarylphosphines have been widely used among the extant click reactions. This review focuses on the azide-based bioorthogonal click chemistry, describing the characteristics and development of these reactions, introducing some recent applications in glycobiology research, especially in glycan metabolic engineering, including glycan non-invasive imaging, glycomics studies and viral surface manipulation for drug discovery as well as other applications like activity-based protein profiling and carbohydrate microarrays. View Full-Text
Keywords: click chemistry; azide; bioorthogonal; glycosylation; glycobiology click chemistry; azide; bioorthogonal; glycosylation; glycobiology
Show Figures

Figure 1

MDPI and ACS Style

Zhang, X.; Zhang, Y. Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules 2013, 18, 7145-7159.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop