Sesquiterpenoids from the Herb of Leonurus japonicus
1
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China
2
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
3
Chengdu No.1 Pharmaceuticlco. Ltd., Chengdu 610031, Sichuan, China
*
Authors to whom correspondence should be addressed.
Molecules 2013, 18(5), 5051-5058; https://doi.org/10.3390/molecules18055051
Received: 10 April 2013
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Revised: 24 April 2013
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Accepted: 25 April 2013
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Published: 29 April 2013
(This article belongs to the Section Natural Products Chemistry)
Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
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Keywords:
Leonurus japonicus; sesquiterpenoids; bioactivities
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MDPI and ACS Style
Xiong, L.; Zhou, Q.-M.; Peng, C.; Xie, X.-F.; Guo, L.; Li, X.-H.; Liu, J.; Liu, Z.-H.; Dai, O. Sesquiterpenoids from the Herb of Leonurus japonicus. Molecules 2013, 18, 5051-5058. https://doi.org/10.3390/molecules18055051
AMA Style
Xiong L, Zhou Q-M, Peng C, Xie X-F, Guo L, Li X-H, Liu J, Liu Z-H, Dai O. Sesquiterpenoids from the Herb of Leonurus japonicus. Molecules. 2013; 18(5):5051-5058. https://doi.org/10.3390/molecules18055051
Chicago/Turabian StyleXiong, Liang, Qin-Mei Zhou, Cheng Peng, Xiao-Fang Xie, Li Guo, Xiao-Hong Li, Juan Liu, Zhao-Hua Liu, and Ou Dai. 2013. "Sesquiterpenoids from the Herb of Leonurus japonicus" Molecules 18, no. 5: 5051-5058. https://doi.org/10.3390/molecules18055051
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