Molecules 2013, 18(5), 5051-5058; https://doi.org/10.3390/molecules18055051
Sesquiterpenoids from the Herb of Leonurus japonicus
1
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China
2
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
3
Chengdu No.1 Pharmaceuticlco. Ltd., Chengdu 610031, Sichuan, China
*
Authors to whom correspondence should be addressed.
Received: 10 April 2013 / Revised: 24 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013
(This article belongs to the Section Natural Products Chemistry)
Abstract
Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP. View Full-TextKeywords:
Leonurus japonicus; sesquiterpenoids; bioactivities
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Xiong, L.; Zhou, Q.-M.; Peng, C.; Xie, X.-F.; Guo, L.; Li, X.-H.; Liu, J.; Liu, Z.-H.; Dai, O. Sesquiterpenoids from the Herb of Leonurus japonicus. Molecules 2013, 18, 5051-5058.
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