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Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

1
Department of Chemistry, Vinh University, Vinh 42000, Vietnam
2
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
3
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
4
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
5
Department of Natural Science, Hong Duc University, Thanhhoa 41000, Vietnam
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2013, 18(4), 4477-4486; https://doi.org/10.3390/molecules18044477
Received: 24 January 2013 / Revised: 3 April 2013 / Accepted: 12 April 2013 / Published: 16 April 2013
(This article belongs to the Section Natural Products Chemistry)
In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM. View Full-Text
Keywords: Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage Annona; triterpenoid; diterpenoid; NO inhibition; iNOS; macrophage
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MDPI and ACS Style

Thang, T.D.; Kuo, P.-C.; Huang, G.-J.; Hung, N.H.; Huang, B.-S.; Yang, M.-L.; Luong, N.X.; Wu, T.-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules 2013, 18, 4477-4486. https://doi.org/10.3390/molecules18044477

AMA Style

Thang TD, Kuo P-C, Huang G-J, Hung NH, Huang B-S, Yang M-L, Luong NX, Wu T-S. Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production. Molecules. 2013; 18(4):4477-4486. https://doi.org/10.3390/molecules18044477

Chicago/Turabian Style

Thang, Tran D., Ping-Chung Kuo, Guan-Jhong Huang, Nguyen H. Hung, Bow-Shin Huang, Mei-Lin Yang, Ngo X. Luong, and Tian-Shung Wu. 2013. "Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production" Molecules 18, no. 4: 4477-4486. https://doi.org/10.3390/molecules18044477

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