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Open AccessArticle

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

1
Center of Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania
2
Research Center Oltchim, St. Uzinei 1, Ramnicu Vilcea 240050, Romania
3
Faculty of Pharmacy, "Ovidius" University, Aleea Universitatii nr.1, Campus Corp B, Constantza 900470, Romania
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(3), 2635-2645; https://doi.org/10.3390/molecules18032635
Received: 29 January 2013 / Revised: 18 February 2013 / Accepted: 18 February 2013 / Published: 27 February 2013
(This article belongs to the Section Organic Chemistry)
Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy. View Full-Text
Keywords: pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition pyrrolo[2,1-a]isoquinoline; one-pot three component; 1,3-dipolar cycloaddition
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Dumitrascu, F.; Georgescu, E.; Georgescu, F.; Popa, M.M.; Dumitrescu, D. Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition. Molecules 2013, 18, 2635-2645.

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