Molecules 2013, 18(11), 13904-13909; https://doi.org/10.3390/molecules181113904
A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
1
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, China
2
School of Life Sciences, Sichuan University, Chengdu 610064, China
3
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
*
Author to whom correspondence should be addressed.
Received: 10 October 2013 / Revised: 29 October 2013 / Accepted: 5 November 2013 / Published: 11 November 2013
Abstract
A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3–5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays. View Full-Text
Figure 1
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Peng, F.; Xiong, L.; Zhao, X.-M. A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules 2013, 18, 13904-13909.
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