A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
Abstract
:1. Introduction
2. Results and Discussion
No. | δH | δC | No. | δH | δC |
---|---|---|---|---|---|
1 | 1.73 m | 31.7 | 12 | 2.37 m | 18.5 |
2 | 2.16 m, 1.72 m | 23.5 | 13 | – | 83.9 |
3 | 4.60 t (3.0) | 78.5 | 14 | 2.47 t (2.4) | 70.6 |
4 | – | 38.0 | 17 | 1.00 s | 27.5 |
5 | 1.97 d (3.0) | 48.5 | 18 | 1.42 s | 24.4 |
6 | 4.19 dd (4.2, 3.0) | 71.4 | 19 | 1.48 s | 22.1 |
7 | – | 198.1 | 20 | 1.81 s | 11.9 |
8 | – | 129.6 | 1ʹ | – | 170.4 |
9 | – | 166.5 | 2ʹ | 1.99 s | 21.0 |
10 | – | 41.5 | OH-6 | 4.53 d (4.2) | – |
11 | 2.58 t (7.8) | 29.5 |
Sample | Dose | APTT (s) | PT (s) | TT (s) | FIB (g/L) |
---|---|---|---|---|---|
Control | Normal saline | 31.22 ± 6.20 | 9.98 ± 0.54 | 53.24 ± 5.91 | 1.59 ± 0.08 |
Compound 1 | 1 mg/mL | 28.88 ± 5.57 ** | 9.87 ± 0.47* | 49.94 ± 3.46 * | 1.64 ± 0.03 * |
0.1 mg/mL | 29.66 ± 4.90 * | 9.94 ± 0.44 | 50.77 ± 4.43 * | 1.66 ± 0.03 * | |
0.01 mg/mL | 31.38 ± 4.87 | 10.00 ± 0.49 | 53.28 ± 3.98 | 1.65 ± 0.06 * |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Blood Coagulation Assay [10]
4. Conclusions
Supplementary Materials
Acknowledgments
Conflicts of Interest
References
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Peng, F.; Xiong, L.; Zhao, X.-M. A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules 2013, 18, 13904-13909. https://doi.org/10.3390/molecules181113904
Peng F, Xiong L, Zhao X-M. A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules. 2013; 18(11):13904-13909. https://doi.org/10.3390/molecules181113904
Chicago/Turabian StylePeng, Fu, Liang Xiong, and Xiao-Mei Zhao. 2013. "A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity" Molecules 18, no. 11: 13904-13909. https://doi.org/10.3390/molecules181113904
APA StylePeng, F., Xiong, L., & Zhao, X.-M. (2013). A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity. Molecules, 18(11), 13904-13909. https://doi.org/10.3390/molecules181113904