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Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii

1
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
2
Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
3
Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan
4
Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan
5
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Molecules 2013, 18(1), 682-689; https://doi.org/10.3390/molecules18010682
Received: 11 December 2012 / Revised: 27 December 2012 / Accepted: 28 December 2012 / Published: 4 January 2013
(This article belongs to the Section Natural Products Chemistry)
Two new diterpenoids, konishone (1) and 3b-hydroxy-5,6-dehydrosugiol (2), along with three known diterpenoids—hinokiol (3), sugiol (4), and 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (5)—were isolated from the wood of Cunninghamia konishii. Compound 1 is a novel skeleton of the 7,20-dinorabietane-type diterpene. In addition, when RAW264.7 macrophages were treated with different concentrations of compounds 1, 3, and 5 together with LPS, a significant concentration-dependent inhibition of NO production was detected. The IC50 values for inhibition of nitrite production of compounds 1, 3, and 5 were about 9.8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs. View Full-Text
Keywords: Cunninghamia konishii; Taxodiaceae; diterpenoid; 7,20-dinorabietane; konishone; 3b-hydroxy-5,6-dehydrosugiol; anti-inflammatory Cunninghamia konishii; Taxodiaceae; diterpenoid; 7,20-dinorabietane; konishone; 3b-hydroxy-5,6-dehydrosugiol; anti-inflammatory
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Chen, Y.-C.; Li, Y.-C.; You, B.-J.; Chang, W.-T.; Chao, L.K.; Lo, L.-C.; Wang, S.-Y.; Huang, G.-J.; Kuo, Y.-H. Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii. Molecules 2013, 18, 682-689.

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