An Improved Synthesis of 1,2-Diarylethanols under Conventional Heating and Ultrasound Irradiation
Abstract
:1. Introduction
2. Results and Discussion
Entry | Base | Solvent | Temperature | Time | Yield (%) a |
---|---|---|---|---|---|
°C | h | ||||
1 | K2CO3 | EtOH | 40 | 5 | 0 |
2 | NaOH | EtOH | 40 | 5 | 5 |
3 | DBU | EtOH | 40 | 5 | 8 |
4 | NaOEt | EtOH | 40 | 5 | 22 |
5 | NaOEt | DMSO | 40 | 5 | 44 |
6 | NaOEt | EtOH:DMSO (6:1) | 40 | 8 | 53 |
7 | NaOEt | EtOH:DMSO (6:1) | 50 | 8 | 62 |
8 | NaOEt | EtOH:DMSO (6:1) | 60 | 8 | 56 |
9 | NaOEt | EtOH:DMSO (6:1) | 70 | 8 | 28 |
Entry | Compound 1 | Compound 2 | Product 3 | Time (h) | Yield (%) a |
---|---|---|---|---|---|
a | 8 | 62 | |||
b | 8 | 65 | |||
c | 12 | 60 | |||
d | 12 | 49 | |||
e | 12 | 58 | |||
f | 12 | 46 | |||
g | 8 | 44 | |||
h | 12 | 45 | |||
i | 8 | 44 | |||
j | 8 | 35 | |||
k | 8 | 53 |
3. Experimental
3.1. General
3.2. General Procedure
4. Conclusions
Acknowledgments
References
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Gao, D.-M.; Ma, W.-L.; Li, T.-R.; Huang, L.-Z.; Du, Z.-T. An Improved Synthesis of 1,2-Diarylethanols under Conventional Heating and Ultrasound Irradiation. Molecules 2012, 17, 10708-10715. https://doi.org/10.3390/molecules170910708
Gao D-M, Ma W-L, Li T-R, Huang L-Z, Du Z-T. An Improved Synthesis of 1,2-Diarylethanols under Conventional Heating and Ultrasound Irradiation. Molecules. 2012; 17(9):10708-10715. https://doi.org/10.3390/molecules170910708
Chicago/Turabian StyleGao, Dong-Mei, Wei-Li Ma, Tian-Rui Li, Liang-Zhu Huang, and Zhen-Ting Du. 2012. "An Improved Synthesis of 1,2-Diarylethanols under Conventional Heating and Ultrasound Irradiation" Molecules 17, no. 9: 10708-10715. https://doi.org/10.3390/molecules170910708