Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
Abstract
:1. Introduction
2. Methods of Synthesis for 2,5-Disubstituted-1,3,4-oxadiazoles
2.1. Methods of Synthesis for 5-Substituted-2-amino-1,3,4-oxadiazoles
2.2. Methods of Synthesis for 5-Substituted-1,3,4-oxadiazole-2-thiols
2.3. Methods of Synthesis for 2,5-Diaryl(alkyl)-1,3,4-oxadiazole
3. Pharmacological Activity of 1,3,4-Oxadiazoles
3.1. Antimicrobial Activity
3.2. Anticonvulsant Activity
3.3. Anti-inflammatory Activity
3.4. Analgesic Activity
3.5. Antitumor Activity
3.7. Antihypertensive Activity
3.8. Enzyme Inhibitors
4. Conclusions
Acknowledgments
Conflict of Interest
References
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De Oliveira, C.S.; Lira, B.F.; Barbosa-Filho, J.M.; Lorenzo, J.G.F.; De Athayde-Filho, P.F. Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012. Molecules 2012, 17, 10192-10231. https://doi.org/10.3390/molecules170910192
De Oliveira CS, Lira BF, Barbosa-Filho JM, Lorenzo JGF, De Athayde-Filho PF. Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012. Molecules. 2012; 17(9):10192-10231. https://doi.org/10.3390/molecules170910192
Chicago/Turabian StyleDe Oliveira, Cledualdo Soares, Bruno Freitas Lira, José Maria Barbosa-Filho, Jorge Gonçalo Fernandez Lorenzo, and Petrônio Filgueiras De Athayde-Filho. 2012. "Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012" Molecules 17, no. 9: 10192-10231. https://doi.org/10.3390/molecules170910192