Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
Abstract
:1. Introduction
2. Results and Discussion
Compd. No. | λmax (log ε) |
---|---|
6a | 385 (3.72), 321 (4.22), 257 (4.63) |
6b | 381 (4.52), 260 (4.57), 231 (4.78) |
6c | 375 (4.02), 282 (4.82), 247 (4.81) |
6d a) | 370 (4.45), 248 (4.63) |
6e | 372 (4.25), 286 (4.26), 231 (4.55) |
6f | 372 (4.10), 328 (4.39), 233 (5.13) |
6g | 346 (3.62), 267 (4.78), 232 (5.01) |
6h | 383 (4.62), 260 (4.54), 234 (4.80) |
6i | 372 (3.94), 260 (3.68), 235 (4.01) |
6j | 381 (4.52), 260 (4.57), 231 (4.78) |
2.1. Anti-Microbial Activity
Microorganism/IZD (mm/mg sample) * | ||||
---|---|---|---|---|
Cpd. no. | EC(G−) | SA (G+) | AF | CA |
Control (DMSO) | 0.0 | 0.0 | 0.0 | 0.0 |
4 | 00 | 9 | 00 | 0.0 |
6a | 12 | 11 | 0.0 | 0.0 |
6b | 00 | 00 | 0.0 | 0.0 |
6c | 00 | 00 | 00 | 00 |
6d | 00 | 00 | 00 | 00 |
6e | 13 | 12 | 00 | 00 |
6f | 00 | 00 | 00 | 00 |
6g | 9 | 00 | 00 | 00 |
6h | 11 | 12 | 00 | 00 |
6i | 11 | 11 | 00 | 00 |
6j | 12 | 12 | 00 | 00 |
Te ** | 31 | 29 | -- | -- |
Am ** | -- | -- | 17 | 20 |
3. Experimental Section
3.1. General
3.2. General Procedure for Synthesis of 3-Arylhydrazono-4-phenyl-[1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones (6a–j).
3.2. Agar Diffusion Well Method to Determine the Antimicrobial Activity
4. Conclusions
References
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Farghaly, T.A.R.; Edrees, M.M.; Abdelnabi Mosselhi, M. Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones. Molecules 2012, 17, 8483-8493. https://doi.org/10.3390/molecules17078483
Farghaly TAR, Edrees MM, Abdelnabi Mosselhi M. Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones. Molecules. 2012; 17(7):8483-8493. https://doi.org/10.3390/molecules17078483
Chicago/Turabian StyleFarghaly, Thoraya Abdel Reheem, Mastoura Mohamed Edrees, and Mosselhi Abdelnabi Mosselhi. 2012. "Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones" Molecules 17, no. 7: 8483-8493. https://doi.org/10.3390/molecules17078483