Next Article in Journal
Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis
Next Article in Special Issue
Improved Methods for Thermal Rearrangement of Alicyclic α-Hydroxyimines to α-Aminoketones: Synthesis of Ketamine Analogues as Antisepsis Candidates
Previous Article in Journal
1H-Nuclear Magnetic Resonance Analysis of the Triacylglyceride Composition of Cold-Pressed Oil from Camellia japonica
Previous Article in Special Issue
The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
Article Menu

Export Article

Open AccessReview
Molecules 2012, 17(6), 6728-6753;

The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth

Department of Biotechnology, Research Institute for Biomedical and Health Science, Konkuk University, Chungju 380-701, Korea
Author to whom correspondence should be addressed.
Received: 30 March 2012 / Revised: 1 May 2012 / Accepted: 28 May 2012 / Published: 4 June 2012
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [316 KB, uploaded 18 June 2014]   |  


Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models. View Full-Text
Keywords: neurite outgrowth; neuroregeneration; neuritogenesis; natural molecules; neurodegeneration neurite outgrowth; neuroregeneration; neuritogenesis; natural molecules; neurodegeneration

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

More, S.V.; Koppula, S.; Kim, I.-S.; Kumar, H.; Kim, B.-W.; Choi, D.-K. The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth. Molecules 2012, 17, 6728-6753.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top