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Open AccessArticle

Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

1
Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
2
Central Research Institute, Shanghai Pharmaceuticals Holding Co., Ltd., Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
Molecules 2012, 17(5), 5497-5507; https://doi.org/10.3390/molecules17055497
Received: 26 March 2012 / Revised: 14 April 2012 / Accepted: 20 April 2012 / Published: 9 May 2012
(This article belongs to the Section Medicinal Chemistry)
A series of novel quinoline-3-carboxamide derivatives 1017 and 2327 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%. View Full-Text
Keywords: CETP inhibitors; CETP; quinoline-3-carboxamide derivatives; synthesis; high density lipoprotein cholesterol CETP inhibitors; CETP; quinoline-3-carboxamide derivatives; synthesis; high density lipoprotein cholesterol
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Li, W.-Y.; Xiong, X.-Q.; Zhao, D.-M.; Shi, Y.-F.; Yang, Z.-H.; Yu, C.; Fan, P.-W.; Cheng, M.-S.; Shen, J.-K. Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors. Molecules 2012, 17, 5497-5507.

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