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Open AccessArticle

A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

Sofia University St. Kliment Ohridski, Faculty of Chemistry and Pharmacy, 1, J. Bourchier Blvd., Sofia 1126, Bulgaria
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Molecules 2012, 17(5), 4936-4949; https://doi.org/10.3390/molecules17054936
Received: 12 March 2012 / Revised: 18 April 2012 / Accepted: 20 April 2012 / Published: 30 April 2012
(This article belongs to the Section Organic Chemistry)
A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined. View Full-Text
Keywords: pyrrolidine-2,5-dione; pyrrolidine; 3-substituted coumarins; 2-oxo-2Н-1-benzopyrane; Michael addition reaction; rearrangement; Nef reaction pyrrolidine-2,5-dione; pyrrolidine; 3-substituted coumarins; 2-oxo-2Н-1-benzopyrane; Michael addition reaction; rearrangement; Nef reaction
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Ilieva, E.D.; Petkova, N.I.; Nikolova, R.D. A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones. Molecules 2012, 17, 4936-4949.

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