Next Article in Journal
The Biological Effects of Ivabradine in Cardiovascular Disease
Previous Article in Journal
Microbial Enhance of Chitosan Production by Rhizopus arrhizus Using Agroindustrial Substrates
Open AccessArticle

Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex

Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(5), 4915-4923; https://doi.org/10.3390/molecules17054915
Received: 14 April 2012 / Revised: 16 April 2012 / Accepted: 16 April 2012 / Published: 30 April 2012
(This article belongs to the Section Natural Products Chemistry)
Two new monoterpene diglycosides, suffruyabiosides A (1) and B (2), and seven known compounds 39 were isolated from Moutan Cortex (root cortex of Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral data. Suffruyabiosides A (1) and B (2) are rare monoterpene diglycosides, including a cellobiose in the molecules. Salicylpaeoniflorin (4) had a antiproliferation effect similar to paeoniflorin (3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (8) and salicylpaeoniflorin (4) revealed a more pronounced radical scavenging effect than a-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [8 > mudanpioside E (6) > oxypaeoniflorin (5)]. Comparison of the effects of 4 and 5 showed that o-substitution with a phenolic hydroxyl group was more effective than p-substitution. The results suggest that salicylpaeoniflorin (4) may be useful as a cytotoxic and a radical scavenging agent. View Full-Text
Keywords: monoterpene diglycoside; suffruyabiosides A and B; human lung adenocarcinoma epitherial A549 cells; radical scavenging effect monoterpene diglycoside; suffruyabiosides A and B; human lung adenocarcinoma epitherial A549 cells; radical scavenging effect
Show Figures

Figure 1

MDPI and ACS Style

Furuya, R.; Hu, H.; Zhang, Z.; Shigemori, H. Suffruyabiosides A and B, Two New Monoterpene Diglycosides from Moutan Cortex. Molecules 2012, 17, 4915-4923.

Show more citation formats Show less citations formats

Article Access Map

1
Only visits after 24 November 2015 are recorded.
Back to TopTop