Two new monoterpene diglycosides, suffruyabiosides A (
1) and B (
2), and seven known compounds
3–
9 were isolated from Moutan Cortex (root cortex of
Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral
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Two new monoterpene diglycosides, suffruyabiosides A (
1) and B (
2), and seven known compounds
3–
9 were isolated from Moutan Cortex (root cortex of
Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral data. Suffruyabiosides A (
1) and B (
2) are rare monoterpene diglycosides, including a cellobiose in the molecules. Salicylpaeoniflorin (
4) had a antiproliferation effect similar to paeoniflorin (
3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (
8) and salicylpaeoniflorin (
4) revealed a more pronounced radical scavenging effect than a-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [
8 > mudanpioside E (
6) > oxypaeoniflorin (
5)]. Comparison of the effects of
4 and
5 showed that
o-substitution with a phenolic hydroxyl group was more effective than
p-substitution. The results suggest that salicylpaeoniflorin (
4) may be useful as a cytotoxic and a radical scavenging agent.
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