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trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness

Dipartimento Scienze della Vita e Biotecnologie-SVEB, UR7 Terra&Acqua Tech-Università di Ferrara, Corso Ercole I d’Este 32, 44121 Ferrara, Italy
Dipartimento di Scienze degli Alimenti, Università di Parma, Viale G.P. Usberti 11A, I-43124 Parma, Italy
Dipartimento Scienze della Vita e Biotecnologie, Sezione Biochimica e Biologia Molecolare, Università di Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy
Author to whom correspondence should be addressed.
Molecules 2012, 17(10), 12393-12405;
Received: 31 August 2012 / Revised: 13 September 2012 / Accepted: 15 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Methods in Polyphenol Analysis)
Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95–105% content of active constituent), four products were slightly out of this range (83–111%) and three were in the 8–64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most “pure”, “high-dosage” supplements may allow a supplementation level adequate to obtain some of the purported health benefits. View Full-Text
Keywords: resveratrol; food supplements; dietary supplements; nutraceuticals; quality control resveratrol; food supplements; dietary supplements; nutraceuticals; quality control
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MDPI and ACS Style

Rossi, D.; Guerrini, A.; Bruni, R.; Brognara, E.; Borgatti, M.; Gambari, R.; Maietti, S.; Sacchetti, G. trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness. Molecules 2012, 17, 12393-12405.

AMA Style

Rossi D, Guerrini A, Bruni R, Brognara E, Borgatti M, Gambari R, Maietti S, Sacchetti G. trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness. Molecules. 2012; 17(10):12393-12405.

Chicago/Turabian Style

Rossi, Damiano, Alessandra Guerrini, Renato Bruni, Eleonora Brognara, Monica Borgatti, Roberto Gambari, Silvia Maietti, and Gianni Sacchetti. 2012. "trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness" Molecules 17, no. 10: 12393-12405.

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