Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. General Method for the Synthesis of Compounds 3a-l
3.2. General Method for the Synthesis of Compounds 3m-p
4. Conclusions
Acknowledgment
References
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Sample Availability: Samples of the substituted N-methyl nitrones 3a-p are available from the authors. |
Substrate | Entry | Reaction Time (min) | Products | mp (or bp) (°C) | mp (or bp) (°C) Lit. | Yield (%) |
---|---|---|---|---|---|---|
1a | 4 | 3a | 82–84 | 82–84 [14] | 94 | |
1b | 5 | 3b | 204–205 | 210–212 [13] | 93 | |
1c | 5 | 3c | 129–130 | 129–130 [17] | 95 | |
1d | 5 | 3d | 102–103 | 103–104 [17] | 98 | |
1e | 7 | 3e | 148–149 | 148–150 [18] | 98 | |
1f | 4 | 3f | 118–119 | 118–119 [17] | 96 | |
1g | 5 | 3g | 90–91 † | - | 96 | |
1h | 8 | 3h | 135–136 ‡ | - | 98 | |
1i | 6 | 3i | 193–195 † | - | 91 | |
1j | 6 | 3j | 113–114 † | - | 93 | |
1k | 3 | 3k | 89–90 | 89–90 [14] | 94 | |
1l | 5 | 3l | oil † | - | 92 | |
1m | 10 | 3m | oil ‡ | - | 62 | |
1n | 10 | 3n | oil ‡ | - | 76 | |
1o | 10 | 3o | (72 °C, 0.1 torr) | (70 °C, 0.1 torr) [19] | 71 | |
1p | 10 | 3p | (88 °C, 0.1 torr) | (80 °C, 0.1 torr) [19] | 68 |
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Yavuz, S.; Ozkan, H.; Colak, N.; Yildirir, Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules 2011, 16, 6677-6683. https://doi.org/10.3390/molecules16086677
Yavuz S, Ozkan H, Colak N, Yildirir Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules. 2011; 16(8):6677-6683. https://doi.org/10.3390/molecules16086677
Chicago/Turabian StyleYavuz, Serkan, Hamdi Ozkan, Naki Colak, and Yilmaz Yildirir. 2011. "Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones" Molecules 16, no. 8: 6677-6683. https://doi.org/10.3390/molecules16086677