Next Article in Journal
3D-QSAR Study of Combretastatin A-4 Analogs Based on Molecular Docking
Previous Article in Journal
Green Synthesis and Antibacterial Effect of Silver Nanoparticles Using Vitex Negundo L.
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(8), 6677-6683;

Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones

Chemistry Department, Faculty of Science, Gazi University, Ankara 06500, Turkey
Chemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı 18100, Turkey
Chemistry Department, Faculty of Science and Arts, Hitit University, Çorum 19030, Turkey
Author to whom correspondence should be addressed.
Received: 20 June 2011 / Revised: 18 July 2011 / Accepted: 19 July 2011 / Published: 8 August 2011
PDF [426 KB, uploaded 18 June 2014]


A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.
Keywords: nitrone; grinding; solid-phase synthesis; solventless nitrone; grinding; solid-phase synthesis; solventless
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Yavuz, S.; Ozkan, H.; Colak, N.; Yildirir, Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules 2011, 16, 6677-6683.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top