Next Article in Journal
Dehydration of (Perfluoroalkyl)tetramethylcyclopentenols
Previous Article in Journal
Apigenin Isolated from the Medicinal Plant Elsholtzia rugulosa Prevents β-Amyloid 25–35-Induces Toxicity in Rat Cerebral Microvascular Endothelial Cells
Article Menu

Export Article

Open AccessArticle
Molecules 2011, 16(5), 4020-4030;

Antioxidant and Cytotoxic Constituents from Wisteria sinensis

Department of Medicinal Chemistry, Theodor Bilharz Research Institute, P.O.B. 12411, Giza, Egypt
Author to whom correspondence should be addressed.
Received: 5 February 2011 / Revised: 13 May 2011 / Accepted: 16 May 2011 / Published: 17 May 2011
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [1103 KB, uploaded 18 June 2014]   |  


Chromatographic separation of an aqueous MeOH extract of Wisteria sinensis leaves has yielded six known flavonoids, two triterpene aglycones and the new acylated flavone glycoside chrysoeriol-7-O-[2''-O-(5'''-O-caffeoyl)-β-D-apiofuranosyl]-β-D-glucopyranoside (1). All metabolites were isolated for the first time from the genus Wisteria. Their structures were established on the basis of their chromatographic properties, chemical and physicochemical methods including acid hydrolysis analysis, spectroscopic (UV, 1H- and 13C-NMR) data and confirmed by ESI-MS analysis, as well as two-dimensional NMR (1H-1HCOSY, HMQC and HMBC). Biological studies of the defatted aqueous 80% methanol leaf extract and the major isolates 1, 6 and 7 were undertaken and they are reported herein for the first time to have significant cytotoxic activity against the Hep-G2 tumor cell line in addition to antioxidant activity. View Full-Text
Keywords: Wisteria sinensis; fabeaceae; acylated flavone; cytotoxic; Hep-G2 Wisteria sinensis; fabeaceae; acylated flavone; cytotoxic; Hep-G2

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Mohamed, M.A.; Hamed, M.M.; Abdou, A.M.; Ahmed, W.S.; Saad, A.M. Antioxidant and Cytotoxic Constituents from Wisteria sinensis. Molecules 2011, 16, 4020-4030.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top