Thiophene Derivatives with Antileishmanial Activity Isolated from Aerial Parts of Porophyllum ruderale (Jacq.) Cass.
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. General
3.2. Plant material
3.3. Preparation of dichloromethane extract
3.4. Isolation and identification of active compounds
3.5. Antileishmanial activity
3.5.1. Antipromastigote activity
3.5.2. Anti-amastigote activity
3.6. Cytotoxicity and selectivity index
4. Conclusions
Acknowledgements
References
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Sample Availability: Samples of the compounds are available from the authors. |
IC50 (µg/mL) | CC50 (µg/mL) | SI | |||
---|---|---|---|---|---|
PRO | AMA | Macrophages | PRO | AMA | |
Dichloromethane extract | 60.3 ± 9.2 | 77.7 ± 7.7 | 500 ± 50 | 8.3 | 6.5 |
Active fraction | 57.5 ± 4.5 | 72.5 ± 7.5 | 440 ± 56.6 | 7.6 | 7.8 |
Compound A | 7.7 ± 1.7 | 19.0 ± 4.7 | 370 ± 50 | 48.2 | 19.1 |
Compound B | 21.3 ± 4.4 | 28.7 ± 2.6 | 335 ± 15 | 15.7 | 11.7 |
Amphotericin B | 0.06 ± 0.0 | 0.23 ± 0.0 | ND | ND | ND |
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Takahashi, H.T.; Novello, C.R.; Ueda-Nakamura, T.; Filho, B.P.D.; Palazzo de Mello, J.C.; Nakamura, C.V. Thiophene Derivatives with Antileishmanial Activity Isolated from Aerial Parts of Porophyllum ruderale (Jacq.) Cass. Molecules 2011, 16, 3469-3478. https://doi.org/10.3390/molecules16053469
Takahashi HT, Novello CR, Ueda-Nakamura T, Filho BPD, Palazzo de Mello JC, Nakamura CV. Thiophene Derivatives with Antileishmanial Activity Isolated from Aerial Parts of Porophyllum ruderale (Jacq.) Cass. Molecules. 2011; 16(5):3469-3478. https://doi.org/10.3390/molecules16053469
Chicago/Turabian StyleTakahashi, Helena Teru, Cláudio Roberto Novello, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, João Carlos Palazzo de Mello, and Celso Vataru Nakamura. 2011. "Thiophene Derivatives with Antileishmanial Activity Isolated from Aerial Parts of Porophyllum ruderale (Jacq.) Cass." Molecules 16, no. 5: 3469-3478. https://doi.org/10.3390/molecules16053469