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Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Rd., Hangzhou 310003, China
Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China
Author to whom correspondence should be addressed.
Molecules 2011, 16(4), 3146-3151;
Received: 31 March 2011 / Revised: 11 April 2011 / Accepted: 12 April 2011 / Published: 14 April 2011
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Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future. View Full-Text
Keywords: aromatase; Atractylodes macrocephala; atractylenolide aromatase; Atractylodes macrocephala; atractylenolide

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Jiang, H.; Shi, J.; Li, Y. Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz. Molecules 2011, 16, 3146-3151.

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