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Molecules 2011, 16(4), 3037-3047;

An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus

Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia
Author to whom correspondence should be addressed.
Received: 18 February 2011 / Revised: 10 March 2011 / Accepted: 10 March 2011 / Published: 8 April 2011
(This article belongs to the Section Natural Products Chemistry)
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This study was designed to investigate the antimicrobial activity of Cinnamomum iners standardized leave methanolic extract (CSLE), its fractions and isolated compounds. CSLE and fractions were subjected to disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests using different Gram positive and Gram negative bacteria and yeast. Within the series of fractions tested, the ethyl acetate fraction was the most active, particularly against methicillin resistant Staphylococcus aureus (MRSA) and Escherichia coli, with MIC values of 100 and 200 µg/mL, respectively. The active compound in this fraction was isolated and identified as xanthorrhizol [5-(1, 5-dimethyl-4-hexenyl)-2-methylphenol] by various spectroscopic techniques. The overall results of this study provide evidence that Cinnamomum iners leaves extract as well as the isolated compound xanthorrhizol exhibit antimicrobial activity for both Gram negative and Gram positive pathogens, especially against MRSA strains. View Full-Text
Keywords: Cinnamomum iners; antimicrobial activity; xanthorrhizol Cinnamomum iners; antimicrobial activity; xanthorrhizol

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Mustaffa, F.; Indurkar, J.; Ismail, S.; Shah, M.; Mansor, S.M. An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus. Molecules 2011, 16, 3037-3047.

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