In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Cytotoxic Activity
Compound | IC50 (µM) | ||
---|---|---|---|
MCF-7 | MDA-MB-231 | DHF | |
1 | >100 | >100 | >100 |
2 | >100 | >100 | >100 |
3 | >100 | >100 | >100 |
4 | 55.5 ± 6.7 | 62.7 ± 4.8 | >100 |
3. Experimental
3.1. General
3.2. Chemistry: Synthesis of 2,9-Dimethoxymethyl-3-diphenylphosphinylboldine (4)
3.3. Cell Lines
3.4. In vitro Growth Inhibition Assay
4. Conclusions
Acknowledgements
References and Notes
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Thomet, F.A.; Piñol, P.; Villena, J.; Reveco, P.G. In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine. Molecules 2011, 16, 2253-2258. https://doi.org/10.3390/molecules16032253
Thomet FA, Piñol P, Villena J, Reveco PG. In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine. Molecules. 2011; 16(3):2253-2258. https://doi.org/10.3390/molecules16032253
Chicago/Turabian StyleThomet, Franz A., Pablo Piñol, Joan Villena, and Patricio G. Reveco. 2011. "In Vitro Cytotoxic Evaluation of a Novel Phosphinyl Derivative of Boldine" Molecules 16, no. 3: 2253-2258. https://doi.org/10.3390/molecules16032253