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Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves

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Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, University of Toulouse, University of Paul-Sabatier, 118 route de Narbonne, F-31062 Toulouse, France
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Laboratoire d’Ecologie et de Technologie Microbienne, Institut National des Sciences Appliquées et de la Technologie (INSAT), Université Carthage, B.P. 676, 1080 Tunis, Tunisia
3
Laboratoire des Substances Biologiquement Actives, Centre de Biotechnologie à l’Ecopark de Borj-Cedria, BP-901, Hamman-Lif 2050, Tunisia
*
Authors to whom correspondence should be addressed.
Molecules 2011, 16(12), 10592-10603; https://doi.org/10.3390/molecules161210592
Received: 3 October 2011 / Revised: 23 November 2011 / Accepted: 2 December 2011 / Published: 19 December 2011
(This article belongs to the Section Medicinal Chemistry)
In this work, an evaluation of the biological activities of Globularia alypum L. extracts and their global chemical composition was realized. Extracts from G. alypum were obtained by two extraction methods. The composition of polyphenols (8.5–139.95 g gallic acid equivalent/Kg of dry mass), tannins (1.39–18.65 g catechin equivalent/Kg of dry mass), anthocyanins (8.17–70.69 mg cyanidin equivalent/Kg of dry mass) and flavonoids (0.31–19.28 g quercetin equivalent/Kg of dry mass) was evaluated. The samples were subjected to a screening for their antioxidant activities using the DPPH· and ABTS·+ assays. For the first time, the anti-tuberculosis activity (H37Rv) for G. alypum was tested against Mycobacterium tuberculosis. The strongest antioxidant activity was obtained for the methanol extract (IC50 = 15.58 ± 0.168 mg/L) and the best anti-tuberculosis activity was obtained for the petroleum ether extract (IC50 = 77 mg/L). We have found a positive correlation between the total phenolics content and the antioxidant activity R2 = 0.88 (DPPH·) and R2 = 0.97 (ABTS·+). We have found also a positive correlation between the flavonoid content and the antioxidant activity R2 = 0.91 (DPPH·) and R2 = 0.91 (ABTS·+). View Full-Text
Keywords: Globularia alypum L.; polyphenols; antioxidant activity; anti-tuberculosis activity Globularia alypum L.; polyphenols; antioxidant activity; anti-tuberculosis activity
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Khlifi, D.; Hamdi, M.; Hayouni, A.E.; Cazaux, S.; Souchard, J.P.; Couderc, F.; Bouajila, J. Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves. Molecules 2011, 16, 10592-10603.

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