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Helichrysum gymnocephalum Essential Oil: Chemical Composition and Cytotoxic, Antimalarial and Antioxidant Activities, Attribution of the Activity Origin by Correlations

1
Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, University of Toulouse, University of Paul-Sabatier, 118 route de Narbonne, F-31062 Toulouse, France
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Nat’Ex Biotech. Bat 7, 55 avenue Louis Breguet, 31400 Toulouse, France
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Laboratoire de Phytochimie et Standardisation, IMRA, BP: 3833 Antananarivo 101, Madagascar
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Faculté of Pharmacy, University of Toulouse, UMR 152 IRD-UPS Pharma-DEV, University of Paul Sabatier Toulouse 3, 35 chemin des maraîchers, 31062 Toulouse Cedex 9, France
*
Author to whom correspondence should be addressed.
Molecules 2011, 16(10), 8273-8291; https://doi.org/10.3390/molecules16108273
Received: 19 September 2011 / Revised: 23 September 2011 / Accepted: 23 September 2011 / Published: 29 September 2011
(This article belongs to the Section Medicinal Chemistry)
Helichrysum gymnocephalum essential oil (EO) was prepared by hydrodistillation of its leaves and characterized by GC-MS and quantified by GC-FID. Twenty three compounds were identified. 1,8-Cineole (47.4%), bicyclosesquiphellandrene (5.6%), γ-curcumene (5.6%), α-amorphene (5.1%) and bicyclogermacrene (5%) were the main components. Our results confirmed the important chemical variability of H. gymnocephalum. The essential oil was tested in vitro for cytotoxic (on human breast cancer cells MCF-7), antimalarial (Plasmodium falciparum: FcB1-Columbia strain, chloroquine-resistant) and antioxidant (ABTS and DPPH assays) activities. H. gymnocephalum EO was found to be active against MCF-7 cells, with an IC50 of 16 ± 2 mg/L. The essential oil was active against P. falciparum (IC50 = 25 ± 1 mg/L). However, the essential oil exhibited a poor antioxidant activity in the DPPH (IC50 value > 1,000 mg/L) and ABTS (IC50 value = 1,487.67 ± 47.70 mg/L) assays. We have reviewed the existing results on the anticancer activity of essential oils on MCF-7 cell line and on their antiplasmodial activity against the P. falciparum. The aim was to establish correlations between the identified compounds and their biological activities (antiplasmodial and anticancer). β-Selinene (R² = 0.76), α-terpinolene (R² = 0.88) and aromadendrene (R² = 0.90) presented a higher relationship with the anti-cancer activity. However, only calamenene (R² = 0.70) showed a significant correlation for the antiplasmodial activity. View Full-Text
Keywords: Helichrysum gymnocephalum; GC-MS; antimalarial activity; cytotoxic activity; antioxidant activity Helichrysum gymnocephalum; GC-MS; antimalarial activity; cytotoxic activity; antioxidant activity
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Afoulous, S.; Ferhout, H.; Raoelison, E.G.; Valentin, A.; Moukarzel, B.; Couderc, F.; Bouajila, J. Helichrysum gymnocephalum Essential Oil: Chemical Composition and Cytotoxic, Antimalarial and Antioxidant Activities, Attribution of the Activity Origin by Correlations. Molecules 2011, 16, 8273-8291.

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